Why we need to redefine the term 'asthma'

A new understanding of our immune system

Pulmonologists define asthma as follows: "It is a chronic and paroxysmal, inflammatory disease of the airways that is associated with an increased sensitivity of the bronchi to various stimuli".

However, now that the true causes of asthma have been identified and published, we need to explain the term “asthma” in a different way.

New definition of asthma

Bronchial asthma is a chronic inflammatory disease of the airways (bronchi), often associated with a dry and painful cough.Allergic asthma is caused primarily by killer enzymes in the diet or detergents, or by the modern indoor climate.

What are the key features of allergic asthma?

The main characteristic of allergic asthma is the formation of IgE (immunoglobulin E) in the body. This is the body's natural weapon for fighting foreign bodies. For asthma sufferers, this means that an allergen has already passed through the skin, even though there is no apparent wound. If an allergen passes through the skin, then there is an allergic reaction; if the allergen cannot pass through the skin, then there is no allergic reaction.

How does an allergen pass through the skin?

Human skin cells are closely linked, effectively forming a barrier which prevents anything from penetrating the surface. The junction between two skin cells consists of protein gates, which are referred to as “tight junctions”. They hold the cells together, allow the skin to excrete unwanted waste products and to admit recognised substances. If these tight junctions are destroyed, anything small enough can enter the body, such as grass pollen constituents or other allergens. As long as these allergens are unable to penetrate the skin and enter the body, they are harmless. A healthy skin ensures that such allergens do not get into the body.

The war of the molecules on a nanometric scale

Tight junctions are extremely small - a thousand times smaller than a pollen particle - so pollen itself cannot enter the body. However, the pollen enzyme within the pollen particle is even smaller - smaller than the distance between two cells. Pollen enzymes and tight junctions are measured on the scale of nanometers (millionths of a meter). When the tight junctions of an asthma sufferer are closed there will be no signs of asthma – no wheezing, no cough. However, when the tight junctions are open, either temporarily by a secondary process or actually destroyed, then allergens can enter the body and the immune system reacts vigorously. The battle of the immune system against the allergen takes place at the molecular level and in the nanometric range.

An asthmatic person needs to know what is causing the destruction, or unintentional opening, of his tight junctions. Clearly he needs to know exactly how to prevent this, in order to remain asthma-free.

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